On Earth, the cardinal directions are straightforward. The arrow on a compass points to the nearest magnetic pole. You can then use it to travel anywhere on Earth.
In space, the idea of anything being “central” enough to be used as a “North” (since the universe has no center) or being fixated enough to not somehow pose issues is more convoluted.
If you were a pioneer of space exploration, what would your “North” be?
We could assign it to any point within a recognizable region in the Cosmic Microwave Background, which would probably be the most universally-applicable reference available. One just needs to be able to filter out the noise from surrounding celestial bodies. The CMB does slowly change over time, but so too does the position of stars within galaxies and galaxies relative to one another.